abstract：:We describe a patient with bronchiolitis obliterans organizing pneumonia (BOOP) requiring respiratory support and treated with corticosteroids and cytoxan for presumed Wegener's granulomatosis (WG). The diagnosis of WG was based on clinical presentation and strongly positive stains for anti-neutrophilic cytoplasmic an...

journal_title：Rheumatology international

authors： Staud R,Ramos LG

更新日期：2001-04-01 00:00:00

abstract：:We report on a 69-year-old woman who presented with myalgia, hearing impairment, fever, night sweats, weight loss, muscular weakness, paresthesia, hypesthesia, and hypalgesia. Sural nerve biopsy showed demyelinative and axonal polyneuropathy due to necrotizing vasculitis with fibrinoid necrosis. A positive test for an...

journal_title：Rheumatology international

authors： Meyer MF,Hellmich B,Kotterba S,Schatz H

更新日期：2000-12-01 00:00:00

abstract：:We report a case of reversible sensorineural hearing loss due to hydroxychloroquine (HQ) treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis (RA). She developed reversible hearing loss after 5 months of HQ treatment. Sensorineural deafness has previously been reported with chloroquine tr...

journal_title：Rheumatology international

authors： Seçkin U,Ozoran K,Ikinciogullari A,Borman P,Bostan EE

更新日期：2000-01-01 00:00:00

abstract：:Biological markers of inflammation are useful for the diagnosis and monitoring of inflammatory rheumatic diseases. The present study tested, whether serum amyloid A (SAA) could be used as a marker of inflammatory disease activity in ankylosing spondylitis (AS). In 72 patients with AS, the two valuable surrogate marker...

journal_title：Rheumatology international

authors： Lange U,Boss B,Teichmann J,Klör HU,Neeck G

更新日期：2000-01-01 00:00:00

abstract：:The aim of the study was to evaluate the frequency of extra-articular manifestations (EAMs) of rheumatoid arthritis (RA) in a series of patients from nine Italian rheumatology clinics. A total of 587 patients underwent direct questioning, complete physical evaluation, and review of medical records and laboratory data....

journal_title：Rheumatology international

authors： Cimmino MA,Salvarani C,Macchioni P,Montecucco C,Fossaluzza V,Mascia MT,Punzi L,Davoli C,Filippini D,Numo R

更新日期：2000-01-01 00:00:00

abstract：:The aim of this study was to evaluate whether cyclosporin A (CsA) influences the radiological disease progression in early rheumatoid arthritis (RA) patients in comparison with other disease-modifying drugs (DMARDs). A total of 103 early RA patients, without prior use of DMARDs, were randomized to receive CsA (3 mg/kg...

journal_title：Rheumatology international

authors： Drosos AA,Voulgari PV,Katsaraki A,Zikou AK

更新日期：2000-01-01 00:00:00

abstract：:Echocardiographic examination and 24-h electrocardiographic Holter monitoring were carried out on 35 patients with nodular rheumatoid arthritis (RA) and 35 with non-nodular RA, who were matched with the nodular RA group regarding age, sex and BSA. A further 35 patients with osteoarthrosis and spondyloarthrosis matched...

journal_title：Rheumatology international

authors： Wisłowska M,Sypuła S,Kowalik I

更新日期：1999-01-01 00:00:00

abstract：:This study aims to elucidate plasma oxidant/antioxidant status in patients with rheumatoid arthritis (RA). Fasting blood samples were obtained from 24 patients with RA and 20 control subjects. Antioxidant potential (AOP) value, nonenzymatic superoxide radical scavenger activity (NSSA), and malondialdehyde (MDA) levels...

journal_title：Rheumatology international

authors： Oztürk HS,Cimen MY,Cimen OB,Kaçmaz M,Durak I

更新日期：1999-01-01 00:00:00

abstract：:Ankylosing spondylitis is a rather uncommon condition in the UAE. Over a period of 10 years. 28 hospital-based patients diagnosed as having AS were retrospectively studied. They included 17 Arabs and 11 Asians. The onset of AS in most patients in this study was in adulthood (mean age at onset was 27.7 years in Arabs a...

journal_title：Rheumatology international

authors： al Attia HM,Sherif AM,Hossain MM,Ahmed YH

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study was to evaluate whether the serum concentration of interleukin-6 (IL-6) reflects disease activity in ankylosing spondylitis (AS). A group of 271 AS patients were enrolled in the study, 261 of whom completed the entire protocol (201 males, 60 females, median age of 53 years). Serum IL-6 was measur...

journal_title：Rheumatology international

authors： Falkenbach A,Herold M

更新日期：1998-01-01 00:00:00

abstract：:Aseptic loosening is the predominant cause of total hip implant failure. It has been assumed that a layer or membrane, containing macrophages, fibroblasts and vascular endothelial cells, of synovial-like tissue develops at the implant-to-bone interface almost invariably and, with time, somehow leads to loosening of th...

journal_title：Rheumatology international

authors： Xu JW,Konttinen YT,Li TF,Waris V,Lassus J,Matucci-Cerinic M,Sorsa T,Santavirta TS

更新日期：1998-01-01 00:00:00

abstract：:The purpose of the present study was to evaluate the toxicity and tolerability of methotrexate (MTX)/gold (G; group 1) combination therapy as compared to other MTX combinations [MTX with hydroxychloroquine (HCQ; group 2), MTX with sulphasalazine (SASP; group 3) and MTX with minocycline (MNC; group 4)]. The hospital re...

journal_title：Rheumatology international

authors： Elkayam O,Yaron M,Zhukovsky G,Segal R,Caspi D

更新日期：1997-01-01 00:00:00

abstract：:The objective of this research was to investigate the cellular source of soluble ICAM-1 (siCAM-1) from rheumatoid synovial tissue (RS) and its relation to sICAM-1 in synovial fluid (SF) and serum, and to study the expression of ICAM-1 in isolated cells of RS. sICAM-1 was determined by using the enzyme-linked immunosor...

journal_title：Rheumatology international

authors： Krenn V,Schedel J,Döring A,Huppertz HI,Gohlke F,Tony HP,Vollmers HP,Müller-Hermelink HK

更新日期：1997-01-01 00:00:00

abstract：:In this study we compared cytokine production and cell proliferation of immunocompetent cells derived from patients with ankylosing spondylitis (AS) to those from healthy blood donors using a whole blood assay. To this end, blood cell cultures were stimulated with the superantigens MAS (Mycoplasma arthritidis supernat...

journal_title：Rheumatology international

authors： Brand JM,Neustock P,Kruse A,Alvarez-Ossorio L,Schnabel A,Kirchner H

更新日期：1997-01-01 00:00:00

abstract：:In spite of differences in etiology, RA and OA lead to astonishingly similar synovitic alterations. Fibroblastic transformation of the synovial membrane and an increase in monocytes constitute a rare but highly characteristic feature of RA. Monocytes synthesize factor (F) XIII, implying that FXIII (a and s) in synovia...

journal_title：Rheumatology international

authors： Plenz A,Fritz P,König G,Laschner W,Saal JG

更新日期：1996-01-01 00:00:00

abstract：:Patients with rheumatoid arthritis (RA) showed significantly (P < 0.01) increased numbers of granulocytes in their peripheral blood compared with normal donors and patients with osteoarthritis, and this finding correlated with interleukin-6 and C-reactive protein levels and active joint score. Then, 17 patients with R...

journal_title：Rheumatology international

authors： Fujimori J,Yoshino S,Koiwa M,Hirai H,Shiga H,Hayama N,Iino Y

更新日期：1996-01-01 00:00:00

abstract：:The efficacy and tolerability of aceclofenac (100 mg bid; n = 109), a new non-steroidal anti-inflammatory agent, was compared to that of indomethacin (50 mg bid; n = 110) in a multi-centre, 12-week, randomized, double-blind clinical trial in patients with rheumatoid arthritis. The efficacy of aceclofenac, on the basis...

journal_title：Rheumatology international

authors： Kornasoff D,Maisenbacher J,Bowdler J,Raber A

更新日期：1996-01-01 00:00:00

abstract：:We examined the intracellular mechanisms of substance P induced oxyradical production in rheumatoid synovial cells by the luminol-dependent chemiluminescence method. After stimulation with substance P (30 microM), single synovial A (macrophage-like) or B (fibroblast-like) cells released oxyradicals such as superoxide ...

journal_title：Rheumatology international

authors： Tanabe T,Otani H,Mishima K,Ogawa R,Inagaki C

更新日期：1996-01-01 00:00:00

abstract：:3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at ...

journal_title：Rheumatology international

authors： Ehrlich W,Huser H,Kröger H

更新日期：1995-01-01 00:00:00

abstract：:Agalactosyl IgG [Gal(0)] was first discovered in patients with rheumatoid arthritis (RA). However, the proportion of this glycoform is also raised in tuberculosis and leprosy. This has helped reinforce the suggestion that RA may be triggered by a mycobacterium-like slow bacterial infection. On the other hand, arthriti...

journal_title：Rheumatology international

authors： McCulloch J,Zhang YW,Dawson M,Harkiss GD,Peterhans E,Vogt HR,Lydyard PM,Rook GA

更新日期：1995-01-01 00:00:00

abstract：:The efficacy and tolerability of aceclofenac, a new non-steroidal anti-inflammatory drug (NSAID) was compared to that of ketoprofen in a multicentre, double-blind, prospective, randomized study of 3-months duration in patients with rheumatoid arthritis. One hundred and sixty-nine patients, aged between 22 and 70 years...

journal_title：Rheumatology international

authors： Martín-Mola E,Gijón-Baños J,Ansoleaga JJ

更新日期：1995-01-01 00:00:00

abstract：:Using different monoclonal antibodies, we performed an immunofluorescent technique on labial salivary glands in order to investigate the immunological phenomena involved in Sjögren's syndrome (SS). An aberrant expression of HLA-DR molecules was detected on cytoplasm of epithelial labial salivary cells in 9 out of 19 (...

journal_title：Rheumatology international

authors： Caretto A,Ostuni PA,Chieco-Bianchi F,Pedini B,Spadaccino AC,Bagnasco M,Todesco S,Betterle C

更新日期：1995-01-01 00:00:00

abstract：:We studied and characterized anti-bovine beta 2-glycoprotein I antibodies (aB beta 2-GPI) in sera from patients with antiphospholipid syndrome (APS) by ELISA. Bovine beta 2-glycoprotein I (beta 2-GPI) was purified by heparin affinity and DEAE ion-exchange chromatography, and identified on immunoblots using a monoclona...

journal_title：Rheumatology international

authors： Nomura M,Okada J,Kondo H

更新日期：1995-01-01 00:00:00

abstract：:Seronegative spondylarthropathies are disorders with the same predisposing antigen, namely HLA B27, a class I molecule of the HLA system. The mechanisms of the different diseases are unknown, and there is no proof of immune system participation. We have investigated patients with spondylarthropathies in order to searc...

journal_title：Rheumatology international

authors： Toussirot E,Lafforgue P,Boucraut J,Despieds P,Schiano A,Bernard D,Acquaviva PC

更新日期：1994-01-01 00:00:00

abstract：:Anaemia of chronic disease (ACD) is a common extra-articular manifestation of rheumatoid arthritis (RA). Tumour necrosis factor alpha (TNF alpha) plays an important role in the development of ACD. The objective of the present study was to assess inhibition of in vitro colony-forming unit erythrocyte (CFUe) and blast-f...

journal_title：Rheumatology international

authors： Jongen-Lavrencic M,Peeters HR,Backx B,Touw IP,Vreugdenhil G,Swaak AJ

更新日期：1994-01-01 00:00:00

abstract：:We studied the depletion and repopulation of synovial lining cells in mice. A single intra-articular injection of liposomes encapsulating the drug dichloromethylene diphosphonate (CL2MDP) in the mouse knee joint caused selective elimination of synovial lining cells. Depletion of cells occurred within a few days as evi...

journal_title：Rheumatology international

authors： van Lent PL,van den Bersselaar L,van den Hoek AE,van de Ende M,Dijkstra CD,van Rooijen N,van de Putte LB,van den Berg WB

更新日期：1993-01-01 00:00:00

abstract：:In patients suffering from ankylosing spondylitis (AS) HLA-B27 determination by means of the microlymphocytotoxicity test (MLCT) sometimes gives equivocal or false-negative results even though it has been performed with meticulous care. These failures of the test did not arise when the isolated mononuclear cells (MNC)...

journal_title：Rheumatology international

authors： Neumüller J,Fischer M,Eberl R

更新日期：1993-01-01 00:00:00

abstract：:Interleukin-6 (IL-6) was detected at low levels in plasma [0.014 +/- 0.006 ng/ml (mean +/- SEM] and in high amounts in synovial fluid [SF; 2.6 +/- 2.2 ng/ml (mean +/- SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR (n = 15) or with histological parameters of acut...

journal_title：Rheumatology international

authors： Sack U,Kinne RW,Marx T,Heppt P,Bender S,Emmrich F

更新日期：1993-01-01 00:00:00

abstract：:A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee. The studies were...

journal_title：Rheumatology international

authors： Porzio F

更新日期：1993-01-01 00:00:00

abstract：:The objective of this study was to determine whether levels of soluble receptors for tumor necrosis factor type I and type II (sTNF-RI and sTNF-RII) as measured in paired synovial fluids (SF) of arthritis patients are associated with clinical or laboratory parameters of local inflammation. sTNF-RI and -RII were measur...

journal_title：Rheumatology international

authors： Miltenburg AM,Aderka D,van Laar JM,Wallach D,Breedveld FC

更新日期：1993-01-01 00:00:00

abstract：:The case of a 29-year-old white female with a 7-year history of typical scleroderma is presented who developed excessive fibrosis of the supraclavicular lymph nodes. After 3 years of disease, firm right supraclavicular lymphadenopathy appeared, accompanied by a high fever. Biopsy revealed non-caseating granulomas and ...

journal_title：Rheumatology international

authors： Andonopoulos AP,Tzanakakis G

更新日期：1993-01-01 00:00:00

abstract：:Baseline and sequential liver biopsies were performed in ten patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) for more than 4 years. Liver biopsies were performed in all patients before the initiation of MTX therapy and were repeated after reaching a cumulative dose of 1500 mg or more. In four p...

journal_title：Rheumatology international

authors： Tishler M,Caspi D,Halperin Z,Baratz M,Moshkowitz M,Yaron M

更新日期：1992-01-01 00:00:00

abstract：:To study the mechanisms of chondrocyte damage, chondrocyte cytotoxicity as shown by chromium-51 release induced by polymorphonuclear leukocytes (PMNLs) was examined. PMNLs significantly enhanced chondrocyte cytotoxicity in the presence of phorbol dibutyrate. This chondrocyte damage was abolished by the addition of cat...

journal_title：Rheumatology international

authors： Saura R,Matsubara T,Hirohata K,Itoh H

更新日期：1992-01-01 00:00:00

abstract：:C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum a...

journal_title：Rheumatology international

authors： Holme ER,Veitch J,Johnston A,McKay IC,Whaley K

更新日期：1992-01-01 00:00:00

abstract：:In this cross-sectional study a comparison was made of rheumatoid factor (RF) isotypes in 203 RF positive patients with arthritis. Of these, 129 had rheumatoid arthritis (RA) and 74 a milder disease that would formerly have been classified as probable RA. The majority (74%) of the RA patients had elevations of two or ...

journal_title：Rheumatology international

authors： Jónsson T,Valdimarsson H

更新日期：1992-01-01 00:00:00

abstract：:Using commercially available antigens, enzyme-linked immunosorbent assays (ELISAs) were set up to demonstrate antibodies of IgG class against Sm and SS-A. Anti-Sm antibodies were demonstrated in 40% of patients with systemic lupus erythematosus (SLE), in 12% of patients with SJögren's syndrome, in 6% of patients with ...

journal_title：Rheumatology international

authors： Gripenberg M,Teppo AM,Friman C

更新日期：1991-01-01 00:00:00

abstract：:Antibodies to DNA are quite specific for systemic lupus erythematosus (SLE) and occur in the majority of SLE patients. Therefore, their detection is an important diagnostic aid to the clinician. Detection of anti-dsDNA may precede the diagnosis of SLE by more than a year. Fluctuations in the level of anti-dsDNA in an ...

journal_title：Rheumatology international

authors： Smeenk RJ,van den Brink HG,Brinkman K,Termaat RM,Berden JH,Swaak AJ

更新日期：1991-01-01 00:00:00

abstract：:The distribution of tumour necrosis factor alpha (TNF alpha) in rheumatoid synovium has been investigated. Ten rheumatoid synovia were compared with seven normal synovia and a range of other tissues, using one polyclonal and six monoclonal antibodies. A common staining pattern was obtained with five reagents. Absence ...

journal_title：Rheumatology international

authors： Wilkinson LS,Edwards JC

更新日期：1991-01-01 00:00:00

abstract：:IgM, IgG and IgA class antibodies against Yersinia, Salmonella, Campylobacter and Borrelia were determined by enzyme-linked immunosorbent assay (ELISA) in a group of 340 unselected patients with a recent inflammatory joint disease. The control group consisted of 340 and 100 healthy blood donors using Borrelia-ELISA an...

journal_title：Rheumatology international

authors： Mäki-Ikola O,Viljanen MK,Tiitinen S,Toivanen P,Granfors K

更新日期：1991-01-01 00:00:00

abstract：:When rheumatoid articular cartilage samples were incubated with normal peripheral blood monocytes and cultured synovial cells in the presence of recombinant human interleukin-1 (IL-1) in vitro, large numbers of monocytes were seen to be attached to the articular surface. Significant numbers of monocytes invaded the ca...

journal_title：Rheumatology international

authors： Ishikawa H,Ohno O,Saura R,Matsubara T,Kuroda T,Hirohata K

更新日期：1991-01-01 00:00:00